Changes in Serum Alkaline phosphatase Isoenzymes associated with Diabetes Mellitus, Fasting and Aging in the Rat
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چکیده
We have determined the effect of diabetes mellitus and starvation/re-feeding on serum alkaline phosphatase (ALP) isoenzymes in the rat. Both ketotic (DKA) and nonketotic (NKDM) diabetic rats showed elevated total ALP activity, primarily due to an increase in intestinal and bone/liver ALP isoenzyme in the NKDM and DKA groups, respectively. There was a decrease in intestinal ALP activity in 3 day starved rats which was reversed after re-feeding for 5 days. Aging was associated with a fall in the bone/liver isoenzyme. This latter change was mainly attributed to a fall in the “bone fraction” of the bone/liver ALP isoenzyme. Since in humans bone/liver and intestinal ALP activity is altered by diabetes mellitus and feeding may increase intestinal ALP, the rat models may be useful in the study of the variables that influence ALP.
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